Introduction Conventional anterolateral surgical approach to the lateral tibial condyle has been well studied and proven safe. However, this approach does not provide adequate visualization for performing a good quality osteosynthesis in fractures located in the posterior segment of the lateral condyle. Purpose of the investigation was a rationale of plate implantation technique on the posterior surface of the lateral tibial condyle from the posterior approach with anatomical and clinical demonstration of its technical feasibility and safety. Materials and methods The study was conducted on 10 knee joints of six unfixed cadavers. We implanted a T-plate on the posterior surface of the lateral tibial condyle using a posterior surgical approach. After that soft tissues were dissected to explore the exact location and the distances between the plate and crucial anatomic structures of the region. Five patients underwent surgical treatment of tibial plateau fractures 41C3 type following AO/OTA classification or Schatzker classification type V using the described method. The patients were followed-up for nine months after surgery. Results were evaluated using the KSS and Lysholm scales. Results The study on cadavers showed safety and feasibility of the surgical technique developed. We did not encounter specific complications associated with posterior plate implantation. All fractures healed after nine months postsurgery. The functional outcomes according to KSS scale were excellent in four cases and good in one case; according to Lysholm scale, three were excellent, one good and one fair outcome. Discussion In spite of the simplicity of the conventional anterolateral approach, many investigators tend to use different modifications of posterior approaches for the posterior lateral tibial condyle fixation. This method provides better reduction and fixation using a buttress plate. Our investigation showed safety and feasibility of this technique for fixation of the posterior segment of the lateral tibial condyle. The technique proposed, if performed properly, provides safe and accurate osteosynthesis and prevents secondary displacements of fragments in the rehabilitative period.

Introduction Swelling is a common complication following a foot and ankle surgery, and is one of the most prevalent complaints that patients present at the clinics. While it affects patients’ satisfaction, the relevance between the swelling and clinical outcome remains unclear. Material and Methods This study assessed volume of foot and ankle swelling in 112 patients with history of ankle fusion, the patients’ Foot Function Index (FFI) score, and patients’ satisfaction. The relationships between swelling volume and early outcomes were analysed with Pearson’s correlation coefficient and a scatter plot. Results The mean of swelling volume increase was 120.0 ± 96.2 ml (range 5 ~ 400 ml); pre-operative FFI score mean was 73.7 ± 4.8 % (range 68 % ~ 81 %), 3 months post-operative FFI score mean was 32.8 ± 5.0 % (range 22 % ~ 56 %) and satisfaction scale’s median was 1 (satisfied). In the correlation analysis, while the meaningful Pearson’s correlation coefficient was found with satisfaction scale, swelling volume showed a weak correlation of Pearson’s correlation test with FFI scores (R value = 0.190; p value = 0.045). Conclusions This study revealed that the swelling of the foot and ankle following ankle fusion surgery are not associated with functional clinical outcome. However, because it affects the patients’ satisfaction, we emphasize the need to identify the problem and management of the swelling, while assuring them that the swelling does not correlate with the early functional outcome.

Introduction Total joint replacement is one of the most effective and successful surgical interventions. Regular monitoring of these surgical interventions is essential and may serve as a system for early detection of defective prosthesis designs or techniques resulting in the complication rate which exceeds the estimated level. The ideal way to conduct this monitoring is a registry of joint replacements. Purpose Assessment of the structure of primary knee joint arthroplasty at the Federal State Budgetary Institution Vreden National Medical Research Centre for Traumatology and Orthopaedics named and it’s comparative analysis with the data from leading foreign registers to improve the work of orthopaedic surgeons, traumatologists and healthcare organizers by optimizing the surgical tactics in the specialized treatment of patients. Methods The authors reviewed the annual reports published by national registers of knee replacements and compared them with the data of the registry of the Vreden National Medical Research Centre for Traumatology and Orthopaedics to make conclusions that would be relevant to current orthopaedic practice. Results Several results of the survey demonstrate the most significant or unexpected conclusions as according to the registry. These include an extremely large gender imbalance and obesity as two thirds of the patients were overweight. The number of patients with tumors and rheumatological diseases in the structure of knee replacements decreased considerably in the recent years. Designs and types of implants used, patellar resurfacing in arthroplasty, time of surgical intervention and options for postoperative administrations of antibiotics at the Vreden Centre are consistent with general European trends in knee arthroplasty. Conclusions The number of primary knee replacements (including unicompartment replacements) has been increasing annually. The patients admitted for primary knee replacement are statistically very similar to patient population from other countries. The main differences are associated with an earlier age at which arthroplasty is performed, an extreme gender imbalance and a relatively low number of patellar resurfacing in primary knee replacement. The problem of overweight among the population leads to an increased number of knee replacements, complications and lower implant survival rate.

Introduction Hip joint arthroplasty combined with shortening osteotomy is a technically difficult surgical intervention. Transection of the femur is possible both with the free-hand method and with the use of special devices. Purpose To evaluate the efficiency of using a special device for shortening osteotomy in total hip arthroplasty in comparison with the operations performed without an osteotomy guide. Materials and methods There were 16 hip replacement surgeries that included shortening osteotomy performed in patients with high dislocation of the femur. The group was divided into 2 subgroups: the study subgroup (8 cases), in which a special device was used for osteotomy, and the control subgroup (8 cases). We used clinical and radiographic study methods, and assesssed the Harris Hip Score (HHS) before and after treatment. Results Duration of the intervention and intraoperative blood loss in the first subgroup were shorter than in the control group but the difference was not statistically significant. The mean HHS increased significantly in the whole group. The midterm HHS in the study subgroup was 85.4 ± 1.9 points, which slightly differed from the control (81.9 ± 1.2 points). The mean follow-up period was 40 ± 8 months. There were two cases of nonunion in the osteotomy site and one case of transient sciatic neuropathy. Two patients with nonunion of the femoral fragments were treated by plating and bone grafting. Conclusion The use of a special device for subtrochanteric osteotomy technically simplifies the arthroplasty procedure in patients with high dislocation of the femur, shortens the operation time and reduces blood loss.

Introduction The article considers the situation with modern user’s applications for patients in the post-operative period after surgical interventions, including total hip replacement. The main reasons for the emergence of a multidisciplinary field of a science, in particular between the medical and IT industries, were formulated. The aim of the study was to develop a technology for preventive analysis, control and management of patient actionsat the stage of outpatient medical rehabilitation by developing and implementing a universal software platform of an application and a chatbot on a mobile device and PC. Material and methods The study presents a universal software platform on a mobile device and a PC, in which the doctor introduces personalized indications based on existing clinical recommendations that permit to target the patient's behavior in an expert-based vector of preventive measures. The paper presents the database scheme, usage scenarios, interface, and an example of a recommendation for a random patronage day. Results The comparative results in the aspect of complications in the patients who used the software product after discharge from the hospital with those in the patients without software patronage were analysed. The overall percentage of complications and of each specific one among them was significantly more frequent in the comparison group than in the observation group with IT-based support (р less 0.001). Patient satisfaction with the app was studied based on an anonymous survey, and a high satisfaction rate was revealed. Discussion The introduction of the software product into clinical work in comparison with existing analogues provided better patients’ compliance, especially in older persons with cognitive comorbidity, to targeted behavioral information, prevention of non-compliance with the medication dosage regimen and mobile activity, thus improving the long-term treatment results in patients at the stage of the rehabilitation. Conclusion It has been concluded that the results of the study indicate the feasibility and clinical validity of the development and implementation of the application developed and of similar software products.

Introduction Hip-salvage treatment in femoral head necrosis has a great social and economic importance.The number of hip joint replacements in young patients has been increasing. Purpose To evaluate the results of hip-preserving surgical interventions in the treatment of patients with non-traumatic femoral head necrosis. Materials and methods The study included 42 cases treated by minimally invasive core decompression of the femoral head and bone grafting, 22 cases of decompression and introduction of autologous bone marrow and mesenchymal stem cells into the core of necrosis, and six cases of using a titanium locking mesh implant. Results The follow-up time after surgery was up to 5 years. The survival rate of hip-reserving operations using cell technology to stimulate osteoregeneration were noticeably better than using bone grafting only in disease stages I, IIA, IIB, IIC. For femoral head osteonecrosis in stage IIIA, a titanium locking femoral head implant has been developed. It promotes regeneration and performs a supporting function. Conclusion The analysis of long-term results of these minimally invasive technologies has proven their efficacy and safety along with a low rate of complications.

Introduction Acetabular dysplasia associated with ischemic deformity of the proximal femur leads to significant functional limitations and progressive hip osteoarthritis (OA). The best surgical approach, the timing and the volume of surgery are still controversial. Material and methods Outcomes of 32 patients with ischemic hip deformity were reviewed. The mean age at the time of surgery was 15.8 ± 0.7 (range, 12–24) years. The mean follow-up period was 4.2 ± 0.4 years. Clinical outcomes were measured using the Merle d'Aubigné-Postel, Tönnis, Severin scoring scales and the grading system developed at the National Ilizarov Medical Research Center for Trauma and Orthopedics (NIMRC TO). Extra-articular (n = 24) and intra-articular (n = 8) procedures were produced for hip reconstructions. Results The hip function score was 5.2 ± 0.1 after extra-articular interventions and 4.3 ± 0.14 after intra-articular procedures. Postoperatively, hip joints were+ graded as Severin IIa (n = 18), Severin IIb (n = 10) and Severin III (n = 4). No arthritic changes occurred in 25 hips. In the remaining cases, OA either progressed (n = 4) or improved (n = 3). Outcomes were rated as good with 2.6 ± 0.03 scores (n = 17), fair with 2 ± 0.1 scores (n = 13)and poor with 1.41 ± 0.05 scores (n = 2) measured on the NIMRC TO scale. Conclusion The technologies offered for the reconstruction of both articular components have been shown to be effective in treatment of patients with ischemic hip deformity and associated acetabular dysplasia

Introduction Typical consequences of Legg-Calve-Perthes disease (LCPD) in its severe stage are pathological changes in the anatomy of the hip joint which lead to functional disorders of the musculoskeletal system, clinically manifested by limp. Objective To study biomechanical characteristics of walking in children with unilateral Legg-Calve-Perthes disease to determine the functional state of the musculoskeletal system after surgical treatment with the use of various methods. Material and methods Temporal and dynamic parameters of gait were studied in 31 patients with unilateral Legg-Calve-Perthes disease aged from 8 to 13 years old. They were examined two to five years after surgical treatment. In the control group of patients (15 children), varus osteotomy (VO) was performed. In the main group (16 children), triple pelvic osteotomy (TPO) was used. All children were operated in the disease stages II–IV corresponding to the classifications of S.A. Reinberg (1964) and to groups III–IV according to the classification of Catterall (1971). To objectify the study, 18 healthy children of the same age without signs of orthopaedic pathology were examined. Gait biomechanics were studied using the STEDIS complex (Neurosoft LLC, Ivanovo) that includes a set of platformless inert sensors "Neurosens" that record the data on accelerations in three mutually perpendicular planes. The temporal characteristics of the gait cycle and shock loads during walking were recorded. Results After surgical treatment, the biometrics of the support and shock load phases in both groups of children with LCPD did not reach the level of healthy individuals. It indicates preservation of deviations in walking parameters. The least significant asymmetry between the affected and unaffected limb were detected in patients after TPO, compared with patients after VO in whom the asymmetry of temporal parameters in the phase of the forefoot rocker and asymmetry of shock loads in the phases of rocking over the heel and ankle joint were preserved. Conclusion After ТPO operations in patients with LCPD, the gait was closer to the physiological one in comparison with patients after VO who retained a non-optimal motor stereotype. The reasons for such differences in motor activity between the groups of patients lies in the gluteal muscle dysfunction due to high position of the greater trochanter after corrective (varus) femur osteotomy and iatrogenic shortening of the affected limb. Triple pelvic osteotomy lacks these negative effects.

Objective Assess the immune status of children with ischemic deformity of the proximal femur taking into account the treatment outcome. Material and methods Preoperative assessment of the immune status was performed for 16 adolescents with ischemic deformity of the proximal femur. Patients' age was 14.4 ± 0.45 years. Immunological parameters of 12 adolescents with satisfactory (group I) and 4 patients with poor (group II) anatomical and functional outcome of surgical treatment were compared. Peripheral blood lymphocyte typing was produced with laser cytometry assay, and IgA, IgM, IgG, IgE, IL-18, IFNγ and circulating immune complexes were quantified with enzyme-linked immunoassay. Results Сomparative analysis of preoperative immunological parameters showed statistically significant decline of Т-helper cells (СD3+СD4+), high levels of activated СD3+CD25 and СD3+HLADR T lymphocytes, low levels of activated NК cells (СD8dimCD38+) and IFNγ in group II. Humoral immune parameters indicated to low levels of IgA, IgM, IgG and higher levels of circulating immune complexes in group II relative to group I. Conclusion Preliminary data obtained suggest that cellular and humoral immune deficiency can be associated with unfavorable outcome of joint preservation procedure. Such immunological parameters as T lymphocytes subpopulation, immunoglobulins, circulating immune complexes and IFNγ can be used as significant prognostic factors for preoperative planning and postoperative rehabilitation of adolescents with ischemic deformity of the proximal femur.

Patients with cerebral palsy (CP) experience pain through the lifespan. The hip joint is the main source of nociceptive input. Use of nonopioid adjuvant medication and regional anesthesia for hip surgeries can be an integral part of a perioperative strategy to decrease opioid use. Regional anesthesia can be delivered efficiently and safely for pediatric orthopedic patients. Objective To compare different regional anesthetic techniques used for multi-level lower limb orthopedic surgeries in children with moderate and severe CP. Material and methods A prospective randomized comparative clinical trial enrolled 101 CP patients who underwent unilateral multi-level lower limb surgery for spastic hip displacement or subluxation. According to a type of anesthesia used, patients were allocated into 3 groups: patients receiving prolonged epidural analgesia (PEA) and fentanyl for sedation (PEAF, n = 32); patients receiving PEA and benzodiazepine for sedation (PEAB, n = 37), and patients receiving a continuous femoral plus single-shot sciatic nerve block and benzodiazepines for sedation (FSNBB, n = 32). Hemodynamic findings, pain intensity, a need for opioids and additives (NSAIDs), the level of sedation and complication rate were evaluated. Results The use of NSAIDs (paracetamol) was significantly higher in PEAB and FSNBB groups as compared to PEAF patients with fentanyl administered, and there were no statistically significant differences in the level of pain recorded with the r-FLACC score among the study groups. There were no statistically significant differences in the level of sedation and agitation measured with the Ramsay Sedation Scale and Richmond Agitation-Sedation Scale (RASS) among the groups at early postoperative period. Apnoea as a complication was observed in a PEAF patient. Conclusion A continuous femoral plus single-shot sciatic nerve block and PEA added with NSAIDs (paracetamol) and benzodiazepines for sedation have shown the comparative effectiveness and safety for a perioperative analgesia of CP patients undergoing multi-levellower limb surgeries as compared to the use of PEA and fentanyl for sedation.

Introduction Fibular hemimelia is a rare congenital malformation of lower limbs with associated deformities of the knee and ankle joints. There is no consensus among the authors regarding the choice of treatment method, appropriate timing of surgery, strategy and postoperative rehabilitation. Objective To explore clinical manifestations of the deformities and review outcomes of pediatric surgical treatment of fibular hemimelia. Material and methods Surgical treatment was performed for 11 children with fibular hemimelia at the Department of Pediatric Orthopedics, RSSPMCTO RUz between 2014 and 2019. Clinical and instrumentation studies were produced for all patients. Results Outcomes of surgical treatment were evaluated using functional characteristics with 7 rated as good and 4 as fair. Conclusion External fixation offers an effective treatment option in the pediatric surgical management of fibular hemimelia

Introduction The Masquelet induced membrane technique is effective in the management of acquired heterogeneous long bone defects and pseudarthrosis.The combination of the Masquelet technology and Ilizarov non-free bone grafting seems promising and reduces the risks of recurrence at long-term in patients with congenital pseudarthrosis. Purpose Presentation of new technological solutions that allow combining the advantages of the Ilizarov bone transport and Masquelet bone grafting in patients with acquired bone defects. Materials and methods Retrospective assessment of the results of bone reconstruction in 10 patients who were treated by a combination of Ilizarov and Masquelet bone grafting technologies to repair long bone defects after failures of previous treatment. Fragments of the biomembrane formed around the cement spacer temporarily replacing the tibial gap after resection bone defect or pseudarthrosis were examined in all patients. The studies were carried out using a Reichard sledge microtome, an AxioScope stereomicroscope and an AxioCam ICc 5 digital camera, a JSM-840 scanning electron microscope and an INCA-200 Energy X-ray electron probe microanalyzer. Results and discussion The combined Masquelet technique and Ilizarov non-free bone plasty provide the conditions that are favorable for reparative processes of the transported fragments. After removal of the spacer, there is a tunnel formed in the interfragmental gap, the walls of which are made of the induced membrane. Bone transport is carried out without technical problems through the compromised tissues which are debrided at the time of distraction initiation, outside the scars. At the same time, there are low risks of inflammation around the transosseous elements; there is no danger of cutting and perforation of soft tissues by transported fragments. Conclusions Complete organotypic rearrangement of the distraction regenerate with the use of Ilizarov non-free bone plasty and the Masquelet technique excludes the possibility of deformities or fractures at the level of newly formed bone areas. Active distraction histogenesis ensures the closure of soft tissue defects without additional reconstructive plastic interventions. The revealed dependence of the induced membrane blood supply on the method of treatment previously used might be a criterion for predicting the treatment outcome in patients with acquired bone defects and pseudarthrosis

Introduction Medication-related osteonecrosis of the jaw (MRONJ) is a complication associated with the intake of osteomodifying agents (bisphosphonates, denosumab). At present, its frequency, according to various authors, may reach from one to 10 cases per 100 subjects. The literature describes the main factors in the pathogenesis of the disease. The prognostic signs of its development, which would allow timely diagnosis and prevention of the disease, remain not fully understood. Materials and methods The retrospective analysis was based on the results of a study of 52 patients with MRONJ who were treated at the Department for Maxillofacial Surgery at the Central City Hospital No. 23 in Yekaterinburg from January 2015 to December 2019 Multispiral computed tomography was used for visualization, quantitative and qualitative assessment of the jaw bone tissue. The optical density of the spongy substance was determined in Hounsfield units (HU) on the side opposite to the lesion. Results The analysis of the results of optical density showed that D1 bone type was not detected in any patient. We observed type D2 using CT in 5 cases in the central part of the lower jaw (9.61 %), in 9 cases in the central part of the upper jaw (17.3 %), as well as in the area of the angle of the lower jaw on 6 CT-scans (11.53 %). D3 and D4 bone types prevailed, D5 bone type was less common. The optical density of the structures under study was in the range from 229.8 ± 56.6 to 534.8 ± 155.4 HU. Thus, patients receiving osteomodifying therapy with bone types D3, D4, D5 are more at risk of developing MRONJ than patients with bone types D1 and D2. Conclusion It is advisable to include a mandatory MSCT with classification of bone types according to Misch and determine optical density of bone tissue in the examination protocols of such patients.

Introduction There is an urgent need for a surveillance system of regular monitoring of specific bacteria inducing various types of osteomyelitis to identify resistant isolates and optimize the use of antibiotics. Objective: monitoring of specific gram-negative bacteria and analysis of the antibiotic resistance of the strains isolated from osteomyelitis patients over a three-year period. Results and discussion P. aeruginosa was the first most common pathogen among gram-negative microorganisms isolated from the patients between 2017 and 2019. Prevalence of the isolates identified in 2019 decreased by 9.6 % as compared to 2017. Next frequently encountered clinical isolates were Enterobacter sp., Acinetobacter sp., Klebsiella sp. There was a twofold increase in K. pneumoniae strains isolated in 2019. Analysis of antibiotic susceptibility testing data revealed multiresistance of the Acinetobacter sp. strains in 2019 despite the total decrease in resistant isolates in 2017 and 2018. Among non-fermenting gram-negative rods, the species being resistant to imipenem were shown to increase by 5.4 times. Overall antibiotic resistance was on rise. Increased antimicrobial resistance to beta-lactam antibiotics also combined with BLaC inhibitors was observed in Enterobacteriaceae population. Meropenem was found to be effective against most bacteria with growing drug resistance observed as compared with recent years. The antibiotic resistance profiles of Klebsiella sp. strains appeared to be high at antimicrobial testing. Conclusion Diverse bacterial morphology of gram-negative species and increasing proportion of drug-resistant strains isolated in osteomyelitis cases have necessitated regular monitoring of multiresistant clinical isolates for adjustment of empirical antibiotic therapies.

Background Short-segment transpedicular screw fixation (SSTSF) is the preferred treatment option for thoracolumbar burst fractures. Adding screws in the fractured body may be helpful in achieving and maintaining fracture reduction. However, the operative approach is disputed. Objective To compare clinical outcomes of transpedicular fixation with and without screws in the fractured vertebral body after isolated uncomplicated fractures at the thoracolumbar junction. Material and methods A retrospective cohort study enrolled 62 patients with Th11–L2 thoracolumbar burst fractures (AOSpine A3, A4) who underwent SSTSF with (n = 32) and without (n = 30) pedicle screws at the fracture level. Demographic data of the patients, operating time and blood loss were registered. Clinical evaluation using Visual analogue scale (VAS ) for pain, Oswestry Disability Index (ODI) to quantify disability and imaging parameters of segmental kyphosis, loss of correction, anterior vertebral body height (AVBH) at the fracture level, spinal canal stenosis (SCS) were measured preoperatively, at one week, 1 month, 6 and 12 months postoperatively. Results The patients of the two groups showed no statistically significant differences in the demographic data, VAS and ODI scores, measurements of kyphotic angle, AVBH, SCS preoperatively (p > 0.05). Screws at the fracture level did not affect the operating time and intraoperative blood loss relative to conventional no-screw group. Benefits with fracture screws were evident at 7 days (p less 0.01) measuring SCS, at 6 months (p less 0.01) and 12 (p less 0.01) months measuring kyphotic angle. There was better kyphosis correction (p less 0.01) and AVBH (p = 0.034) seen at 12 months after surgery. Conclusion Reinforcement of a broken vertebra with fracture-level screws has been shown to provide better stability of clinical and radiographic results as compared to those with conventional SSTSF.

Objective To explore the effect of surgical reconstruction of the local sagittal balance on the outcomes and quality of life in elderly with degenerative low-grade spondylolisthesis. Design: a retrospective non-randomized single center cohort study. Material and methods This article reviewed 110 elderly patients (91 (82.7 %) females and 19 (17.3 %) males) with degenerative spondylolisthesis who underwent surgical treatment at the Federal State Medical Center, Novosibirsk. The mean age was 66 years (range, 60 to 83 years). Radiography, spiral computed tomography, MRI of the lumbar spine were performed for all patients who were also asked to use the visual analog scale and the Oswestry disability index (ODI). Sagittal spino-pelvic radiographic parameters including PI, SS, PT, LL, SL (Segmental Lordosis), LL4–S1 (Lordosis L4–S1) were measured and related to age. Global lumbar lordosis measurements were made using the formula: LL = 0.54 × PI + 27.6°. Comorbidity assessment was produced with the body mass index (BMI) and the Charlson Comorbidity Index (CCI). Patients were subdivided into three groups according to the severity of the sagittal imbalance as described by Barrey: (1) balanced, (2) balanced with compensatory mechanisms and (3) imbalanced, and their outcomes evaluated. Results Increased body weight was observed in 97.3 % of patients. The mean BMI was 33.7. A comorbid condition was detected in all patients (n = 110). The mean CCI was 57.4 %. The mean PI was 57.4°. Most of patients (n = 95, 86.4 %) had significant segmental imbalance due to the loss of segmental lordosis at the lower lumbar motion segments. Pelvic retroversion was identified as the compensatory mechanism in the pelvis area in 95 % of patients with measurements of PT based on the available PI. A statistically significant increase in LL4-S1 was observed in the groups due to reduction of spondylolisthesis and restoration of the segmental lordosis. A statistically significant increase in LL was observed in the imbalanced group only. No statistically significant differences in ODI scores were observed in TLIF and ALIF/LLIF patients. Complications graded in the Clavien-Dindo classification were identified in 65 (59 %) cases with greater complication rate in TLIF patients (n = 59, 69 %), as compared to ALIF/LLIF (n = 6, 24 %). From them, 5 (0.5 %) were graded IIIB. Conclusion Differentiated use of surgical technologies and MIS is the method of choice for elderly patients with comorbidities. Patients with compensated sagittal balance can benefit from direct spinal canal decompression, reduction and stabilization of degenerative spondylolisthesis using the posterior approach. Treatment of patients with impaired spino-pelvic balance should be aimed at reduction and restoration of the segmental lordosis (SL) using lordotic cages to ensure good clinical and radiological results.

Objective To study morphological and radiological parameters of facet joints depending on the grade of the intervertebral disk degeneration. Materials and methods To study the facet joints of the lumbar spine in 145 patients with various grades of degeneration according to Pfirrmann and treated using rigid fixation and TLIF technology, MSCT in 2-energy mode and morphological investigation of the intraoperative material were performed. Results In Pfirrmann grade 2, an increase in the volumetric content of chondrocytes, Hounsfield density of the cartilage plate, and the level of Ca in the facet joints was visualized. They indicate that the joint remains functional. In Pfirrmann grade 5, deep pathological changes occurred with violation of the architectonics of the cartilage formations of the facet joints, formation of bone elements and connective tissue growth into the cartilage and bone structures of the joint, which correlated with the results of MSCT. Conclusion The data obtained show that there is a close relationship between morphological and radiological changes in the facet joints. Modulating the data obtained allows us to obtain objective criteria for evaluating the grade of pathological processes in facet joints and use them as a diagnostic component when planning decompression and stabilizing operations in patients with degenerative diseases of the lumbar spine.

Purpose To study the effect of osteoplastic materials based on the extracellular xenomatrix of bovine and equine bone tissue on the formation of neutrophil extracellular traps (NETs) in the peripheral blood of rabbits in the early post-operative period after implantation. Materials and methods The study was carried out on 18 male rabbits of the Soviet Chinchilla breed, aged from 8 months to 1.2 years, weighing from 3.0 to 4.5 kg. A perforated bone defect of a cylindrical shape measuring 2 x 6 mm in the distal metaphysis of the right and left femurs was modeled in the animals. The rabbits were divided into three groups, six animals each. In group I, the bone defect was left unfilled; in group II, the defect was filled with a bovine bone tissue xenomatrix, and an equine bone tissue xenomatrix was implanted in group III animals. The implantation material had the appearance of a yellowish crumb with a particle size of 0.5–1 mm. Blood smears stained according to Romanovsky-Giemsa were used for counting extracellular neutrophil traps (NETs). The percentage of neutrophils that passed the stages of nuclear transformation and emitted free chromatin into the extracellular space in the form of network-like structures was calculated. Results On days 3–7 of the experiment, the number of NETs increased in the early stages of NETosis in all groups. There were no significant differences between the groups. In group I, on days 7 and 14, the number of early forms of NETs (stages 1a and 1b) returned to the values of the preoperative period. In groups II and III, normalization of NETs (stage 1a) did not occur, and the content of NETs (stage 1b) returned to the initial level only by day 30 of the experiment. On days 3, 7, 14, the number of mature NETs increased in all groups. The highest values were noted in group II, where the bovine xenogeneic matrix was implanted. Conclusion Implantation materials based on the extracellular matrix of equine and bovine xenogeneic bone stimulate excessive formation of early NETs on days 14–30 of the experimental period in response to xenotransplantation. Xenomaterials of bovine bone tissue, in comparison with xenomaterials of equine bone tissue, induce a more pronounced inflammatory reaction in the nearest time after defect filling, which is manifested by higher production of mature NETs on days 3–14 of the experiment.

Introduction Aseptic necrosis of the femoral head (ANFH) is one of the orthopedic diseases affecting the socially active population. This fact determines the keen interest of researchers in this nosological type. At present, there is no consensus on the ANFH etiology and pathogenesis, what complicates the choice of treatment tactics. The efficiency of conservative treatment, despite the existence of several options, is currently controversial. The reasons for this remain the ambiguity of research results associated with a low level of evidence, heterogeneity of patients samples, different approaches to studying the efficacy of various treatment methods. The aim of this work is to analyze studies of a high level of evidence on the effectiveness of the use of conservative methods in the treatment of ANFH. Material and methods The study reviews the studies published between 2010 and 2017 (61) available in various information systems (PubMed, eLibrary.ru, etc.). Results The data from the studies of evidence levels I and II showed the ineffectiveness of using the method of joint unloading and lipid-lowering agents in the treatment of patients with ANFH. The use of anticoagulants in idiopathic (primary) ANFH in the pre-collapse stage was justified. The effectiveness of biophysical methods (hyperbaric oxygenation, extracorporeal shockwave therapy and pulsed electromagnetic fields) and cell therapy was confirmed in terms of relieving pain, improving the functional state of the joint and metabolic processes in it at the early stage of the disease. The efficacy of the drug iloprost in eliminating pain and edema in patients with ANFH at an early stage was proven. The opinions of researchers about the effect of bisphosphonates on the results of treatment in patients with ANFH are controversial. Conclusion There is insufficient evidence to prove the effectiveness of any of the conservative treatment methods, but there are studies proving their partial effectiveness. Complete recovery of the joint, as a rule, does not occur, but in most cases it is possible to prevent joint damage, reduce destructive processes in the femoral head and pain, and maintain the functional state of the muscles.

Introduction The scapholunate interosseous ligament binds the scaphoid and lunate together, and is the primary stabilising ligament between these two bones. Scapholunate injuries lead to chronic instability and degenerative arthritis of the wrist. Scapholunate injuries are graded based on the acuity and the severity of the injury. Purpose The paper is a review of various techniques used to repair or reconstruct the scapholunate ligament according to the clinical manifestations, anatomic and pathologic findings. Methods A review of the literature covering this topic is presented. Results Conservative treatment is primarily indicated in stable and partial ligament tears. Arthroscopic treatment is used when immobilization is unsuccessful.Arthroscopically assisted scapholunate reduction and K-wire fixation is commonly used for acute injuries. Primary repair of scapholunate injuries are performed in all tear types using an open approach. Surgical indications depend on the severity of the instability, time after trauma and the presence of degenerative changes. Acute repair of scapholunate ligament injuries remains the gold standard as an earlier intervention provides better results. Acute injuries to the scapholunate ligament require two-four weeks before surgery. Within this period the ligament is often still repairable itself both with or without supplementary capsulodesis procedures; ligament reconstruction is generally preferable in patients with chronic injures. There are many arthroscopic techniques to treat chronic scapholunate injures such as scapholunate ligament primary repair using various types of capsulodesis, tendon graft reconstruction, bone-ligament-bone procedure, various intercarpal fusions and proximal row carpectomy, total wrist fusion and arthroplasty. Conclusion Early diagnosis and management of scapholunate ligament tears are necessary to preserve wrist functions.

Introduction Diagnosis and treatment of vertebrogenic pain syndrome caused by multilevel lumbar spondylolysis is crucial for patients of different age groups. Objective To report a clinical case of diagnosis and treatment of a two-level lumbar spondylolysis in a 16-year-old male patient, and review the relevant literature. Material and methods We had an experience of treatment and follow-up of a 16-year-old athlete who presented with low back pain and was diagnosed with spondylolysis of the pars interarticularis at the L3 and L5 levels. Diagnostic workup included patient history, physical examination, diagnostic imaging (plain radiograph, computed tomography). Scientific publications from modern medical databases were used for literature review. A total of 32 relevant articles brought out between 1975 and 2019 were reviewed. Results The 16-year-old athlete was diagnosed with multilevel spondylolysis of lumbar spine based on patient history, physical examination data and diagnostic imaging of lumbar spine. No pathognomonic clinical findings were revealed. The diagnosis was confirmed with computed tomography. Conservative treatment was initiated for the patient and a long-termfollow-up was available. Literature review included epidemiologic data characterizing multilevel lumbar spondylolysis: the indicence, patients' gender and age. Major etiological factors, common localization of the pathology, the incidence of spondylolysis and spondylolisthesis, treatment strategy including surgical procedures are described. Discussion There is a small number of scientific publications describing different aspects of multilevel spondylolysis of the lumbar spine in the current medical literature. The diagnosis is often delayed for the reason. The natural history of pain in adolescent athletes sustaining the load placed on them in both training and competition can be helpful for timely diagnosis. Conclusion The implications of this clinical case report can be practical for accentuation of multilevel spondylolysis of the lumbar spine among Russian specialists, contribute to medical knowledge and extend to both early diagnosis and efficient management.

Objective Review emerging trends within healthcare sectors internationally to care for spinal conditions in developed Western European and North American countries. Material and methods An explorative review of electronic bibliographic (Scopus, Pubmed, etc.), thesis and dissertation database, organization websites, grey literature resources and reference lists of relevant papers was undertaken to identify the key publication outlets for relevant content between 2016 to 2020. In the present review, the depth of the search was 27 years (post 1994). This review utilized a methodology structured using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-ScR and PRISMA-S preprint) checklist with the description available on https://doi.org/10.17605/OSF.IO/5JGN4. Results The researchers explored the conditions for strong primary spine care providing effective measures and strategies in streamlining patients and examined the appropriateness of referrals for high-technology imaging assessment. Primary care with its integrative function is provided by professionals with specialized training including general practitioners and nurses. Guidance on the management and standards of inpatient care for a diverse and complex range of conditions are of concern with a focus on specialized spinal services providing invasive management strategies for traumatic spinal cord injuries, in particular. Direct access to diagnostic procedures is essential at specialised spinal services providing conservative and surgical management for a acute spinal diseases with the decision making process and care for this group of patients being very complex with little support of evidence based medicine sources. Conclusion Significant input from clinical and support services is required to provide clinical practice guidelines based upon the best available research evidence and practice experience with a greater range of approaches and techniques.

Introduction Central pontine myelinolysis (CPM) is a rare neurologic disorder involving severe damage to the myelin sheath of nerve cells in the pons. Clinical features usually include tetraparesis, pseudobulbar palsy and altered mental status. Objective To review a case of humerus fracture in a female with CPM. Material and methods A 65-year-old patient with CPM sustained humerus fracture that was first treated conservatively. With two neurological examinations and a clinical case conference the humerus fracture of the high-risk patient was nailed. Results No neurological deterioration was observed postoperatively. A satisfactory bone alignment was noted radiologically. The patient was discharged from the hospital with a satisfactory outcome. Discussion The favorable outcome suggests that patients with CPM can benefit from surgical treatment. Conclusion CPM cannot be considered an absolute contraindication for surgical treatment, however, further study is required.

Introduction This article describes a clinical case of a stress fracture of the distal tibial metaepiphysis following a high-energy tibial shaft fracture stabilized with interlocking intramedullary (IM) nail to identify an underlying cause of the traumatic event. Objective To demonstrate the occurrence of a stress fracture after adequate interlocking IM nailing of a traumatic fracture due to systemic osteoporosis that presented no clinical manifestations prior to injury. Material and methods Magnetic resonance imaging was performed to diagnose the stress fracture. Bone mineral density and laboratory markers of bone metabolism were measured to identify underlying causes of the stress fracture. Consolidation of the traumatic fracture fixed with interlocking IM nail was re-evaluated with a radiograph of the fracture site. Results The stress fracture was seen off the IM nail on MRI scans. Osteoporosis was diagnosed with bone densitometry using dual energy X-ray absorptiometry, and deoxypyridinoline, a bone resorption marker and vitamin D deficiency were identified with laboratory tests. No signs of fracture union were seen radiologically. Conclusion A stress fracture of the distal tibial metaepiphysis detected 3 months after a tibial shaft fracture fixed with interlocking IM nail can be considered an insufficiency fracture caused by primary (idiopathic) systemic osteoporosis that was asymptomatic prior to the high-energy injury.