DEGENERATIVE AND DYSTROPHIC CHANGES OF ARTICULAR CARTILAGE AND A TECHNIQUE OF THEIR PHARMACOLOGICAL CORRECTION

Abstract

Viscoelastic properties and chemical composition of articular cartilage was studied in the dogs, which were subjected to the Ilizarov apparatus application to a leg, with intraarticular infusion of chondroprotector and without it. In the cartilage of operated and contralateral limbs changes developed, consisting in decrease of pliability, increase of mineralization degree, break of ratios between monomeric and aggregated proteoglycanes of cellular matrix. Experimental evaluation of the proposed preparation - stimbone-3 - demonstrated, that its use as intraarticular injections almost completely restored mechanical properties of articular cartilage in case of its degenerative involvements.