Personalized aspects of idiopathic osteoarthrosis of the hip joint

Abstract

Objective To reveal personalized predictive criteria of idiopathic osteoarthrosis of the hip joint. Material and methods The study included 100 unrelated patients with grade III–IV idiopathic osteoarthritis of the hip joint, aged 61.3 ± 8.5 years, Russian citizens of Zabaykalsky Krai. Control group consisted of 100 patients of matching age (60 ± 8.3 years), ethnic background and geographic range. Exclusion criteria for the patients were other types of osteoarthritis (post-traumatic, rheumatoid, etc.), acute inflammatory diseases and exacerbations of chronic conditions, and osteoporosis. Clinical, laboratory (polymorphism of genes determined for TLR2-753Arg > Gln, TLR6-249Ser > Pro, FCGR2A-166His > Arg, DEFB1-52G > A, DEFB1-20G > A, TGFb1-25Arg > Pro, TNFα-308G > А, IL4-589C > Т) and radiological methods were employed in the study. Results Statistically significant differences between patients with idiopathic coxarthrosis and control group were observed in carriers of -166Arg genotype / Arg FCGR2A gene (χ2 – 99.2, p less 0.0001, OR – 255.2); -52A genotype / A genes of DEFB1 (χ2 – 58.7, p less 0.0001, OR – 11.2); -20A genotype / A genes of DEFB1 (χ2 – 42.2, p less 0.0001, OR – 8.3) and 589T genotype / T genes of IL4 (χ2 – 49.7, p less 0.0001, OR – 25.2). The detailed personalized analysis of polymorphisms identified in coxarthrosis group showed an early onset and rapid progression of the disease (under 40 years of age) at a simultaneous carriage of 3 and 4 homozygous mutants in the study polymorphisms, whereas carriage of 2 and over homozygous mutants in SNPs genes was not detected in controls. Conclusion Identification of -166Arg genotype / Arg gene of FCGR2A, -52A genotype / A genes of DEFB1, -20A genotype / A genes of DEFB1 and -589T genotype / T genes of IL4 in residents allows for prediction of idiopathic coxarthrosis.