Treatment of open fractures using Bacillus subtilis 804 metabolites containing the fibroblast growth factor

Abstract

Purpose. To improve the methods of treatment of open fractures by local stimulating impacting osteogenesis with Bacillus subtilis 804 metabolites containing the fibroblast growth factor. Materials and methods. In their work the authors used a model of open femoral fracture. They performed osteotomy of the middle femoral third via 1-cm approach with further intramedullary osteosynthesis using a wire in 112 rats. They infused 0.2 ml of Bacillus subtilis 804 metabolites into the fracture zone of 56 rats of the experimental group, 0.2 ml of 0.9% sodium chloride solution – into the fracture zone of 56 rats of the control group. Clinical observations and histological investigations performed. Results and conclusion. As it was found, Bacillus subtilis 804 metabolites possessed a stimulating effect on reparative osteogenesis and accelerated fracture consolidation in experimental animals.