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Biochemical parameters of blood serum in patients with chronic posttraumatic osteomyelitis of the leg during treatment by the Ilizarov method

Abstract

Purpose. To evaluate the biochemical changes in patients’ organism dynamically during posttraumatic osteomyelitis treatment by the Ilizarov method.
Materials and Methods. Blood serum biochemical parameters studied in 15 patients at the age of 20-55 years with chronic posttraumatic osteomyelitis of the leg. The technique of monolocal compression osteosynthesis used in six patients (Group 1). Bilocal distraction-compression osteosynthesis (Group 2) used in nine patients who required additional surgical intervention, tibial osteotomy to fill the developed defect that performed 3-4 months after wound healing and purulent process stopping. The activity of phosphatases, lactate dehydrogenase, creatinase studied, as well as the concentration of general calcium, phosphate, magnesium, general protein, triglycerides, general cholesterol and glycolysis products determined.
Results. The reliable (p less 0.05) decrease of general calcium level, the decrease of acid phosphatase bone isoenzyme activity, the maintenance of glycolysis product elevated concentration – all this found in blood serum of both group patients at the stages of treatment. The content of general protein and inorganic phosphate decreased significantly in Group 1 patients during treatment, while that of triglycerides and general cholesterol – in patients of Group 2.
Conclusion. The character and the depth of blood serum biochemical parameter shifts in patients with chronic posttraumatic osteomyelitis of the leg in the dynamics of treatment by the Ilizarov method depended on the extent of surgery. In this case, the subsequent filling of the defect regardless osteosynthesis technique didn’t lead to substantial metabolic disorders.

Review

For citations:


 ,  ,  ,  ,   Biochemical parameters of blood serum in patients with chronic posttraumatic osteomyelitis of the leg during treatment by the Ilizarov method. Genij Ortopedii. 2013;(2). (In Russ.)

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ISSN 1028-4427 (Print)
ISSN 2542-131X (Online)