Comparative quantitative evaluation of reparative process for implantation of biocomposition materials into bone defects

Abstract

The authors have studied the effect of implantation materials based on calcium-phosphate compounds (CPhC), isolated from mature bovine compact bone tissue, into which both organic matrix derived from bovine bone tissue and polypeptide growth factors isolated from serum of animals with active osteogenesis – serum proteins, were injected to improve osteoinduction properties. Animals were divided into five groups: 1) that without implantation; 2) that where bone defects were filled with CPhC; 3) where bone defects were filled with biocomposite having CPhC and organic matrix in its composition; 4) where bone defects were filled with biocomposite including CPhC and serum proteins; 5) where bone defects were filled with biocomposite containing CPhC, organic matrix and serum proteins. The results of x-ray study and those of the dynamics of defect shadow optical density by the digitized x-ray images have demonstrated that addition of CPhC-based implantation materials composed with both organic matrix and serum proteins contribute to defect filling.