Spatial organization, stereoultrastructure and mineral content of regenerates, formed during primary cranioplasty

Abstract

Bone regenerates, which are formed in defects of skull vault bones during transport of pedicle-provided bone fragments in them, are studied experimentally, in adult dogs. The material is studied by transmission and scanning electron microscopy, light microscopy of semithin sections and roentgen electron-probe microanalysis. It is demonstrated, that structure of the bone regenerates, formed in a defect of skull vault bones, has much in common with that of the regenerates, which are formed in the process of fracture healing in long tubular bones and of distraction osteosynthesis. In all the cases they are formed with reticulofibrous bone tissue, cellular source of which is the same - population of low-differentiated perivascular cells, having osteogenic potentials, which grow into diastasis together with vascular terminals and form growth plate of the regenerates. It is established, that spatial organization of the bone regenerates is determined by their angioarchitectonics.