Clinical-and-pathogenetic aspects of rotation atlas subluxation in children

Abstract

Introduction. The work involves the important problems of rotation atlas subluxation pathogenesis in children related to collagen metabolism disorder and the presence of undifferentiated connective tissue dysplasia. Purpose. To improve the effectiveness of treatment of children with rotation atlas subluxation due to the reveal of pathogenesis clinical-and-diagnostic features.
Material and Methods. Blood serum of 87 children studied. Clinical examination performed with revealing the external signs of undifferentiated connective tissue dysplasia, as well as the level of autoantibodies to I and II collagens determined in blood plasma by the method of solid-phase enzyme immunoassay (EIA).
Results. The level of autoantibodies to I and II collagens increased in blood serum of patients with rotation atlas subluxation (p less 0,05). Direct correlation revealed between dysmorphogenetic signs and collagen metabolism disorders.
Conclusion. The data reflect the conjugation of the external and clinical stigmata of undifferentiated connective tissue dysplasia for rotation atlas subluxation with immunologic shifts in pathogenesis.