Features of bone metabolic processes when using composite porous titanium implants with diamond-like nanocoating

Abstract

The experiment was performed in 26 adult rabbits. The enzyme activity of bone tissue in the implementation of porous titanium implants with a diamond-like coatings (a-C) saturated with autologous adherent bone marrow cells, in the area of bone defects have been investigated. When using PTi (a-C) the features of osseointegration consisted in earlier and more pronounced osteogenesis activation, which was accompanied by activation of bone-specific alkaline phosphatase, as compared with PTi. One of the mechanisms that provided the increasing energy needs of the developing bone was the activation of aerobic processes.