Use of «Kollapan» preparation for the spine osteomyelitis experimentally

Abstract

Aim of Study. To analyze the effect of «Kollapan» preparation on the processes of bone tissue regeneration for the spine experimental osteomyelitis. Materials and Methods. The experimental osteomyelitic defects of rat tail vertebrae were filled with “Kollapan” preparation. Animals were clinically observed in the postoperative period, and histological samples were studied radiographically and morphologically in the periods of one, three and six months. Results. Bone block has been formed by the period of 6 months after surgery when “Kollapan” is used for bone tissue defect filling. Conclusions. The experimental model of the spine chronic osteomyelitis in rats has been developed which allows to study the processes of reparative osteogenesis and “Kollapan” effect on it. Surgical debridement of the spine osteomyelitic process using “Kollapan” material contributes to bone block formation and to complete regression of inflammatory episodes with recurrence absence and animal recovery.