Hemostasis system after the knee endoprosthetics under antithrombotic prevention by Dabigatran direct thrombin inhibitor

Abstract

Aim of the study was to investigate the plasmatic, thrombocytic, endothelial links of hemostasis in 31 patients in the dynamics after the knee endoprosthetics through the prevention with Dabigatran, a direct thrombin inhibitor. Maximal thrombin formation was determined after the surgery completion, its level didn’t differ from the initial value by Day 14. Fibrinolysis was of phased character: intensification after surgery, depression — by Day 3, re-intensification — beginning from Day 7. The increased platelet activity was observed immediately after surgery, being restored up to its initial level in a day. The coagulation index determined by thromboelastography was within the normal limits in the majority of patients examined through significant prolongation of clotting tests. Conclusions. The use of Dabigatran standard dose provides adequate correction of hypercoagulation condition in hemostasis plasmatic link in most patients undergone total endoprosthetics of the knee.