The dynamics of lipid peroxidation and antioxidant activity measurements in patients with deforming osteoarthrosis of the hip after total endoprosthetics with uneventful course and in case of hip instability

Abstract

Biochemical studies of lipoperoxide level and antioxidant activity in 248 patients with uneventful clinical course and 53 patients with clinically, roentgenologically and intraoperatively confirmed endoprosthesis instability after total endoprosthetics of the hip were performed on the basis of the traumatological department of Municipal Clinical Hospital 3. The data obtained have demonstrated the increase of lipoperoxides of all types in patients with deforming osteoarthrosis. The dynamics of lipid peroxidation and antioxidant activity measurements in patients with favorable clinical course was shown to differ from that of patients with subsequent development of endoprosthesis component instability. The substantial increase of lipid peroxidation measaurements through the reduction of antioxidant activity was found in patients with clinically and roentgenographically confirmed hip instability.