The outlooks of pathogenetic treatment of patients with the imperfect osteogenesis using elements of nano-technologies

Abstract

Mineral mass and density have been determined in the process of lower limb bone deformity correction in 15 patients with imperfect osteogenesis using the X-ray double-energy bone densitometer of ―GE/Lunar Corp.‖ firm (USA). Wire bioactive coating with calcium-phosphate compound contributes to local correction of mineral metabolism disorders. The use of intramedullary bioactive reinforcement contributes to consolidation of bone fragments for correcting osteotomy of long bones. Mineralization level increases not only in the zone of fracture, but in the whole skeleton as well. The results of examination have demonstrated that 15-20% increase of mineral density was observed for all skeletal bones in the process of deformity correction. The effect was achieved at the expense of skeletal axis straightening, positive neurohumoral changes and greater motor activity. Calcium-phosphate bioceramics has high biocompatibility and the ability of integration with bone tissue.