genortГений ортопедииGenij Ortopedii1028-44272542-131XЦЕНТР ИЛИЗАРОВА10.18019/1028-4427-2025-31-1-6-11genort-3157Research ArticleОригинальные статьиOriginal articlesРоль сывороточного лактоферрина и кальпротектина в воспалительной реакции у пациентов с переломами костейRole of serum lactoferrin and calprotectin in the inflammatory response in patients with bone fractureshttps://orcid.org/0009-0007-5016-5697AmshaweeA. M.AmshaweeA. M.

Ahmed M. Amshawee — MD

Babylon

Ahmed M. Amshawee — MD

Babylon

ahmed.mekki9@yahoo.comhttps://orcid.org/0009-0001-8958-8079HussainM. A.HussainM. A.

Maryam A. Hussain — MD

Maryam A. Hussain — MD

maryamali94914@gmail.comhttps://orcid.org/0009-0005-3772-0073KhafelM. A.L.KhafelM. A.L.

Mohannd A.L. Khafel — MD

Karbala

Mohannd A.L. Khafel — MD

Karbala

mohanndabdalkareem5@gmail.comhttps://orcid.org/0009-0009-4296-1516AlhusseiniN. B.AlhusseiniN. B.

Nabaa Basim Alhusseini — MD

Najaf

Nabaa Basim Alhusseini — MD

Najaf

nabaab.aljerio@uokufa.edu.iqhttps://orcid.org/0009-0005-2108-1668Al-FahhamA. A.Al-FahhamA. A.

Ali A. Al-Fahham — Professor

Najaf

Ali A. Al-Fahham — Professor

Najaf

fahham925@gmail.comHilla University CollegeИракHilla University CollegeIraqAl-Furat Al-Awsat Technical UniversityИракAl-Furat Al-Awsat Technical UniversityIraqAl-Zahrawi University CollegeИракAl-Zahrawi University CollegeIraqUniversity of KufaИракUniversity of KufaIraq202521022025311611Copyright © Amshawee A.M., Hussain M.A., Khafel M.A., Alhusseini N.B., Al-Fahham A.A., 20252025Amshawee A.M., Hussain M.A., Khafel M.A., Alhusseini N.B., Al-Fahham A.A.Amshawee A.M., Hussain M.A., Khafel M.A., Alhusseini N.B., Al-Fahham A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ilizarov-journal.com/jour/article/view/3157Введение

Введение. Повышенная концентрация сывороточного кальпротектина и лактоферрина позволяет сделать прогноз относительно микрососудистых изменений у пациентов с переломом костей.

Цель работы — оценить диагностическую значимость сывороточного кальпротектина и лактоферрина в развитии воспалительной реакции у пациентов с переломом костей.

Материалы и методы

Материалы и методы. В исследование в период с октября 2021 года по январь 2022 года включены 70  пациентов; из них 40 имели переломы костей и 30 были здоровыми участниками (контрольная группа). Кальпротектин и лактоферрин определяли методом иммуносорбентного анализа.

Результаты

Результаты. У 12 пациентов (30 %) были открытые переломы костей, а у 28 (70 %) — закрытые. Исследование показало, что уровень сывороточного кальпротектина значительно увеличился у пациентов с переломами костей по сравнению со здоровыми участниками, в то время как лактоферрин показал пограничное, но не значительное увеличение (P = 0,06). Пациенты с открытыми переломами костей имели более высокий уровень сывороточного кальпротектина по сравнению с пациентами с закрытыми переломами (P = 0,05). Матрица корреляции показала, что существует сильная положительная корреляция между кальпротектином и лактоферрином у пациентов с переломами костей.

Обсуждение

Обсуждение. Кальпротектин классифицируется как мощный провоспалительный маркер, повышенный при хроническом воспалении, таком как синдром раздраженного кишечника (СРК), атеросклеротических поражениях, различных видах артрита и иммунологическом отторжении. Настоящее исследование лишь подтверждает повышение уровня кальпротектина у пациентов с  переломами костей. Недавно опубликованные исследования указывают на новую потенциальную роль кальпротектина в заживлении костей и риске переломов.

Заключение

Заключение. Высокий уровень сывороточного кальпротектина и лактоферрина указывает на сильный воспалительный статус у пациентов с переломами костей, особенно при открытых переломах.

Introduction Elevated concentrations of serum calprotectin and lactoferrin were observed to make prediction about microvascular changes in patients with bone fractures.

The aim of the present study was to assess the diagnostic value of serum calprotectin and lactoferrin in the development of inflammatory response in patients with bone fractures.

Material and Methods Seventy patients were included in the study between October 2021 and January 2022; of these, 40 had bone fractures and 30 were healthy participants (control group). Calprotectin and lactoferrin were measured by immunosorbent assay.

Results 12 patients (30 %) had open bone fractures while 28 (70 %) had closed bone fractures. The study revealed that levels of serum calprotectin significantly increased in patients with bone fractures as compared to healthy subjects, while lactoferrin exhibited a borderline but not significant increase (P = 0.06). Patients with open bone fractures had higher levels of serum calprotectin compared to those with closed fractures (P = 0.05). The correlation matrix exhibited that there was a strong positive correlation between calprotectin and lactoferrin in patients with bone fractures.

Discussion Calprotectin is classified as a potent pro-inflammatory marker that has been noted to be elevated in  chronic inflammation such as irritable bowel syndrome (IBS), atherosclerotic lesions, different types of arthritis, and immunological rejection. The present study may only confirm an increase in calprotectin in patients with bone fractures. Recently published studies indicate the potential new role of calprotectin in bone healing and fracture risk.

Conclusion High serum calprotectin and lactoferrin indicate a strong inflammatory status in bone fracture patients, especially in those with open fractures.

тотальное эндопротезирование коленного суставаперсонализированное выравниваниекинематическое выравниваниемеханическое выравниваниеартроз коленного суставаcalprotectinlactoferrinbone fractureinflammationАвторы благодарят пациентов и их семьи за сотрудничество в течение периода исследования и выражают благодарность персоналу медицинского центра Al-Sadr Medical City в городе Наджаф (Ирак) за поддержку и сотрудничество во время сбора образцов.The authors want to thank the patients and their families for their cooperation during the study period and express their thanks to the staff of the Al-Sadr Medical City, in Najaf City, in Iraq for their support and cooperation during sample collection.ReferencesToben D, Schroeder I, El Khassawna T, et al. Fracture healing is accelerated in the absence of the adaptive immune system. J Bone Miner Res. 2011;26(1):113-124. doi: 10.1002/jbmr.185.Toben D, Schroeder I, El Khassawna T, et al. 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The authors declare that there are no conflicts of interest present.