genortГений ортопедииGenij Ortopedii1028-44272542-131XЦЕНТР ИЛИЗАРОВА10.18019/1028-4427-2024-30-5-677-686PEBVEGgenort-3062Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВлияние цинксодержащего кальций-фосфатного покрытия на остеоинтеграцию чрескожных имплантатов для протезирования конечностейThe effect of zinc-containing calcium phosphate coating on the osseointegration of transcutaneous implants for limb prostheticshttps://orcid.org/0000-0001-8516-8571СтоговМ. В.StogovM. V.

Максим Валерьевич Стогов — доктор биологических наук, доцент, руководитель отдела

Курган

Maksim V. Stogov — Doctor of Biological Sciences, Associate Professor, Head of Department

Kurgan

stogo_off@list.ruhttps://orcid.org/0000-0003-2890-3597ЕмановА. А.EmanovA. A.

Андрей Александрович Еманов — кандидат ветеринарных наук, ведущий научный сотрудник

Курган

Andrey A. Emanov — Candidate of Veterinary Sciences, Leading Researcher

Kurgan

a_eman@list.ruhttps://orcid.org/0000-0001-8949-6345КузнецовВ. П.KuznetsovV. P.

Виктор Павлович Кузнецов — доктор технических наук, профессор, заведующий лабораторией, профессор кафедры

Курган

Екатеринбург

Viktor P. Kuznetsov — Doctor of Technical Sciences, Professor, Head of Laboratory, Professor of the Department

Kurgan

Ekaterinburg

wpkuzn@mail.ruhttps://orcid.org/0000-0002-0903-6750КомароваЕ. Г.KomarovaE. G.

Екатерина Геннадьевна Комарова — кандидат технических наук, научный сотрудник

Томск

Ekaterina G. Komarova — Candidate of Technical Sciences, Researcher

Tomsk

 

katerina@ispms.ruhttps://orcid.org/0000-0002-9516-7481ГорбачЕ. Н.GorbachE. N.

Елена Николаевна Горбач — кандидат биологических наук, ведущий научный сотрудник

Курган

Elena N. Gorbach — Candidate of Biological Sciences, Leading Researcher

Kurgan

gorbach.e@mail.ruhttps://orcid.org/0000-0002-1006-5217КирееваЕ. А.KireevaE. A.

Елена Анатольевна Киреева — кандидат биологических наук, старший научный сотрудник

Курган

Elena A. Kireeva — Candidate of Biological Sciences, Senior Researcher

Kurgan

ea_tkachuk@mail.ruhttps://orcid.org/0000-0001-7125-484XТолкачеваТ. В.TolkachevaT. V.

Татьяна Викторовна Толкачева — ведущий технолог

Томск

Tatiana V. Tolkacheva — Leading Technologist

Tomsk

tolkacheva@ispms.ruhttps://orcid.org/0000-0001-5037-245XШаркеевЮ. П.SharkeevYu. P.

Юрий Петрович Шаркеев — доктор физико-математических наук, профессор, главный научный сотрудник

Томск

Yurii P. Sharkeev — Doctor of Physical and Mathematical Sciences, Professor, Chief Researcher

Tomsk

sharkeev@ispms.ruНациональный медицинский исследовательский центр травматологии и ортопедии имени академика Г.А. ИлизароваРоссияIlizarov National Medical Research Centre for Traumatology and OrthopedicsRussian FederationНациональный медицинский исследовательский центр травматологии и ортопедии имени академика Г.А. Илизарова; Уральский федеральный университет им. первого Президента России Б.Н. ЕльцинаРоссияIlizarov National Medical Research Centre for Traumatology and Orthopedics; Ural Federal University named after. the first President of Russia B.N. YeltsinRussian FederationИнститут физики прочности и материаловедения Сибирского отделения Российской академии наукРоссияInstitute of Strength Physics and Materials Science of Siberian Branch of Russian Academy of SciencesRussian Federation202418102024305677686Copyright © Стогов М.В., Еманов А.А., Кузнецов В.П., Комарова Е.Г., Горбач Е.Н., Киреева Е.А., Толкачева Т.В., Шаркеев Ю.П., 20242024Стогов М.В., Еманов А.А., Кузнецов В.П., Комарова Е.Г., Горбач Е.Н., Киреева Е.А., Толкачева Т.В., Шаркеев Ю.П.Stogov M.V., Emanov A.A., Kuznetsov V.P., Komarova E.G., Gorbach E.N., Kireeva E.A., Tolkacheva T.V., Sharkeev Y.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.ilizarov-journal.com/jour/article/view/3062Введение

Введение. Повышение интеграции чрескожных имплантатов является важной задачей для их применения в клинической практике.

Цель работы — оценка остеоинтеграции титановых чрескожных имплантатов с кальций-фосфатным покрытием, содержащим ионы цинка.

Материалы и методы

Материалы и методы. Исследования выполнены на 12 кроликах-самцах, которым имплантировали оригинальный имплантат в культю большеберцовой кости. После имплантации на кость устанавливали компрессионное устройство, поддерживавшее нагрузку 3,5Н в течение 5 нед. Длительность наблюдения — 26 недель. Животные разбиты на две группы: группа контроля (n = 6) — имплантировано изделие без покрытия; опытная группа (n = 6) — имплантировано изделие с цинк-замещенным кальций-фосфатным покрытием.

Результаты

Результаты. Выпадение имплантата отмечали в одном случае у животных группы контроля, в опытной группе случаев выпадения имплантатов не отмечено. Выявлено, что весовая концентрация Са и Р во всех зонах костно-имплантационного блока животных опытной группы достоверно превышала аналогичные показатели контрольной группы. В контрольной группе отмечали длительное сохранение высоких значений уровня С-реактивного белка, чего не наблюдали в основной группе.

Обсуждение

Обсуждение. Комплекс исследований показал, что имплантат с цинксодержащим кальций-фосфатным покрытием имеет признаки улучшенной интеграции в отличие от изделия без покрытия. Отсутствие серьезных нежелательных реакций на тестируемые изделия свидетельствует о приемлемой переносимости и безопасности применения.

Заключение

Заключение. При использовании имплантатов с цинк-модифицированным кальций-фосфатным покрытием обнаружены признаки более эффективной остеоинтеграции по сравнению с изделием без дополнительного покрытия.

Introduction Increasing the integration of transcutaneous implants is an important goal for their application in clinical practice.

The purpose of the work was to evaluate the osseointegration of transcutaneous titanium implants with calcium-phosphate coating containing zinc ions.

Materials and methods The studies were performed on 12 male rabbits, who underwent implantation of an original implant into the tibial stump. After implantation, a compression device was installed on the bone, maintaining a load of 3.5 N for 5 weeks. Duration of observation was 26 weeks. The animals were divided into two groups: a control group (n = 6) with an implant without coating and an experimental group (n = 6) with a zinc-substituted calcium-phosphate coated implant.

Results The implant fell out in one case in animals from the control group; no cases of implant loss were noted in the experimental group. It was revealed that the weight concentration of Ca and P in all zones of the bone-implant block of the animals in the experimental group significantly exceeded similar indicators in  the  control group. In the control group, long-term persistence of high levels of C-reactive protein was noted, which was not observed in the experimental group.

Discussion This series of studies has shown that an implant with a zinc-modified calcium-phosphate coating exhibited a more effective integration, in contrast to an uncoated product. The absence of serious adverse reactions to the tested products indicates acceptable tolerability and safety of its use.

Conclusion The implants with a zinc-modified calcium-phosphate coating showed signs of more effective osseointegration compared to the product without additional coating.

протезированиечрескожный имплантатостеоинтеграциякальций-фосфатное покрытиеprostheticstranscutaneous implantosseointegrationcalcium-phosphate coatingИсследование выполнено в рамках государственного задания НМИЦ ТО имени академика Г.А. Илизарова на осуществление научных исследований и разработок на период 2021–2023 и 2024–2026 годов. Получение покрытий на опытных образцах имплантатов и изучение их характеристик выполнено в рамках государственного задания ИФПМ СО РАН (проект № FWRW-2021-0007) и при финансовой поддержке Минобрнауки России в рамках Программы развития УрФУ в соответствии с программой стратегического академического лидерства «Приоритет–2030».The study was carried out within the framework of the state assignment of the Ilizarov National Medical Research Center of Traumatology and Orthopaedics for the implementation of scientific research and development for the period 2021–2023 and 2024–2026. 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The authors declare that there are no conflicts of interest present.