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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">genort</journal-id><journal-title-group><journal-title xml:lang="ru">Гений ортопедии</journal-title><trans-title-group xml:lang="en"><trans-title>Genij Ortopedii</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1028-4427</issn><issn pub-type="epub">2542-131X</issn><publisher><publisher-name>ЦЕНТР ИЛИЗАРОВА</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18019/1028-4427-2023-29-4-395-401</article-id><article-id custom-type="edn" pub-id-type="custom">KWFFNQ</article-id><article-id custom-type="elpub" pub-id-type="custom">genort-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Original articles</subject></subj-group></article-categories><title-group><article-title>Особенности органотопической перестройки костной ткани и имплантируемого костнопластического материала при нейроостеоартропатии Шарко</article-title><trans-title-group xml:lang="en"><trans-title>Features of organotopic remodeling of bone tissue and implanted osteoplastic material in Charcot neuro/osteoarthropathy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4943-3440</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оснач</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Osnach</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Станислав Александрович Оснач – врач-травматолог</p><p>Москва</p></bio><bio xml:lang="en"><p>Stanislav A. Osnach – Traumatologist</p><p>Moscow</p></bio><email xlink:type="simple">stas-osnach@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5077-2186</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Процко</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Protsko</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виктор Геннадьевич Процко – доктор медицинских наук, доцент, руководитель Центра хирургии стопы</p><p>Москва</p></bio><bio xml:lang="en"><p>Victor G. Protsko – Doctor of Medical Sciences, Associate Professor, Head of the Center for Foot Surgery</p><p>Moscow</p></bio><email xlink:type="simple">89035586679@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6287-8132</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Василий Викторович Кузнецов – кандидат медицинских наук, врач травматолог-ортопед</p><p>Москва</p></bio><bio xml:lang="en"><p>Vasily V. Kuznetsov – Candidate of Medical Sciences, Traumatologist-orthopedist</p><p>Moscow</p></bio><email xlink:type="simple">vkuznecovniito@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1276-5484</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оболенский</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Obolensky</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимир Николаевич Оболенский – кандидат медицинских наук, доцент, заведующий отделением</p><p>Москва</p></bio><bio xml:lang="en"><p>Vladimir N. Obolensky – Candidate of Medical Sciences, Associate Professor, Head of Department</p><p>Moscow</p></bio><email xlink:type="simple">gkb13@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8748-0059</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тамоев</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Tamoev</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саргон Константинович Тамоев – кандидат медицинских наук, травматолог-ортопед, заведующий отделением</p><p>Москва</p></bio><bio xml:lang="en"><p>Sargon K. Tamoev – Candidate of Medical Sciences, Traumatologist-orthopedist, head of the department</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7252-1978</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хамидуллина</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khamidullina</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юлия Владимировна Хамидуллина – врач-рентгенолог</p><p>Тольятти</p></bio><bio xml:lang="en"><p>Yulia V. Khamidullina – Radiologist</p><p>Tolyatti</p></bio><email xlink:type="simple">hamidullina1207@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3720-5467</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борзунов</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Borzunov</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитрий Юрьевич Борзунов – доктор медицинских наук, профессор кафедры, доцент, врач травматолог-ортопед</p><p>Екатеринбург</p></bio><bio xml:lang="en"><p>Dmitry Yu. Borzunov – Doctor of Medical Sciences, Professor of the Department, Associate Professor, Traumatologist-orthopedist</p><p>Ekaterinburg</p></bio><email xlink:type="simple">borzunov@bk.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Городская клиническая больница им. С.С. Юдина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital. S.S. Yudina</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова;&#13;
Городская клиническая больница № 13</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University;&#13;
City Clinical Hospital No. 13 of the Moscow Department of Health</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Тольяттинская городская клиническая больница № 5</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tolyatti City Clinical Hospital No. 5</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Уральский государственный медицинский университет;&#13;
Центральная городская клиническая больница № 23</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ural State Medical University;&#13;
Central City Clinical Hospital No. 23</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2023</year></pub-date><volume>29</volume><issue>4</issue><fpage>395</fpage><lpage>401</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Оснач С.А., Процко В.Г., Кузнецов В.В., Оболенский В.Н., Тамоев С.К., Хамидуллина Ю.В., Борзунов Д.Ю., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Оснач С.А., Процко В.Г., Кузнецов В.В., Оболенский В.Н., Тамоев С.К., Хамидуллина Ю.В., Борзунов Д.Ю.</copyright-holder><copyright-holder xml:lang="en">Osnach S.A., Protsko V.G., Kuznetsov V.V., Obolensky V.N., Tamoev S.K., Khamidullina Y.V., Borzunov D.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.ilizarov-journal.com/jour/article/view/11">https://www.ilizarov-journal.com/jour/article/view/11</self-uri><abstract><sec><title>Введение</title><p>Введение. Несмотря на признание МРТ как диагностического «золотого стандарта» при артропатии Шарко, в литературе имеются сведения о большей информативности МСКТ для объективной качественной и количественной диагностики состояния, в первую очередь, костного остова стопы Шарко в сравнении со стандартной рентгенографией. Чувствительность и специфичность указанных методов различны.</p></sec><sec><title>Цель</title><p>Цель. Выявить особенности органотопической перестройки костной ткани и имплантируемого костнопластического материала при замещении субтотальных дефектов среднего и заднего отделов стопы при нейроостеоартропатии Шарко.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведен анализ плотности костной ткани и имплантируемого костнопластического материала в серии наблюдений – 11 пациентов с нейроостеоартропатией Шарко, перенесших двухэтапную методику замещения костных дефектов заднего и среднего отделов стопы с фиксацией аппаратом Илизарова. Изучали КТ- и МРТ-томограммы с измерением плотности костного регенерата до лечения, на этапах чрескостного остеосинтеза и через 3, 6 и 12 месяцев после оперативного вмешательства.</p></sec><sec><title>Результаты</title><p>Результаты. У всех пациентов в разной степени визуализировали увеличение количества и объема костной ткани за счет интенсивного периостального костеобразования, а также формирование костных анкилозов в сочленениях с последовательным увеличением оптической плотности костных регенератов. Формирование новообразованной костной ткани проходило без признаков лизиса и секвестрирования. Проведенные исследования свидетельствуют о том, что размеры и архитектоника костных фрагментов более оптимально дифференцируются на КТ, чем на МРТ.</p></sec><sec><title>Обсуждение</title><p>Обсуждение. Известно, что кость, несмотря на высокую степень минерализации, непрерывно перестраивается, восстанавливается и адаптируется к определенным функциональным условиям. Этот постоянный динамический процесс адаптивной перестройки зависит, главным образом, от оптимального кровоснабжения, метаболической активности и скоординированной работы костных клеточных элементов. Полученные данные свидетельствуют о наличии ангиогенеза в скомпрометированных тканях у пациентов со стопой Шарко и последовательном ремоделировании трансплантата в новообразованную костную ткань.</p></sec><sec><title>Заключение</title><p>Заключение. Наличие аллокости в составе комбинированного костного трансплантата не снижает вероятность полного ремоделирования новообразованной костной ткани. Возможность создания большей денситометрической плотности при заполнении костного дефекта трансплантатом является отличием от дистракционных регенератов с изначально низкой денситометрической плотностью. До выполнения оперативного лечения высокоэффективными и информативными методами диагностики являются КТ и МРТ. При реконструктивных вмешательствах у пациентов со стопой Шарко в условиях чрескостного остеосинтеза предпочтение в выборе лучевых методов исследования необходимо отдавать компьютерной томографии.</p></sec></abstract><trans-abstract xml:lang="en"><p>Introduction Despite the recognition of MRI as the gold diagnostic standard for Charcot arthropathy, there is evidence in the literature that MSCT is more informative for objective qualitative and quantitative diagnosis of the condition, primarily of the bone skeleton of the Charcot foot, in comparison with standard radiography. The sensitivity and specificity of these methods are different.</p><p>Purpose To reveal the features of organotopic remodeling of bone tissue and implanted osteoplastic material in the course of midfoot and hindfoot subtotal defects management in Charcot neuro-osteoarthropathy.</p><p>Materials and methods The analysis of bone tissue and implanted osteoplastic material density was carried out in a case series that included 11 patients with Charcot neuro-osteoarthropathy who underwent a two-stage procedure for bone defects in the hindfoot and midfoot with the Ilizarov apparatus. We studied CT and MRI scans and measured bone regenerate density before treatment, at the stages of transosseous osteosynthesis, and 3, 6, and 12 months after surgery.</p><p>Results In all patients, varying increase in the amount and volume of bone tissue was visualized due to intensive periosteal bone formation along with the formation of bone ankylosis in the joints along combined with a consistent increase in the optical density of bone regenerates. The formation of the new bone tissue ran without the signs of lysis or sequestration. The conducted studies indicate that the sizes and architectonics of bone fragments are more differentiated in CT than in MRI scans.</p><p>Discussion It is known that the bone, despite its high mineralization, continuously rebuilds, restores and adapts itself to certain functional conditions. This constant dynamic process of adaptive remodeling depends mostly on optimal blood supply, metabolic activity and the coordinated work of bone cell elements. The data obtained show angiogenesis in the compromised tissues in patients with Charcot foot and consistent remodeling of the graft into the new bone tissue.</p><p>Conclusion The allobone in the composition of the combined bone graft does not reduce the likelihood of complete remodeling of the newly formed bone tissue. Higher bone density by filling in a bone defect with a graft differs from distraction regenerate that initially has low bone density. CT and MRI are highly effective and informative diagnostic methods for surgical treatment. In reconstructive interventions in the patients with Charcot foot under the conditions of transosseous osteosynthesis, preference among radiological study methods should be given to CT.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>стопа Шарко</kwd><kwd>костная пластика</kwd><kwd>перестройка регенерата</kwd><kwd>лучевые исследования</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Charcot foot</kwd><kwd>bone grafting</kwd><kwd>regenerate remodeling</kwd><kwd>radiological studies</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Галстян Г.Р., Викулова О.К., Исаков М.А. и др. Эпидемиология синдрома диабетической стопы и ампутаций нижних конечностей в Российской Федерации по данным федерального регистра больных сахарным диабетом (2013-2016 гг.). 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